Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy

► We established LAT1 amino-acid transporter-disrupted DT40 cells. ► LAT1-disrupted cells showed slow growth and lost the oncogenicity. ► siRNA and mAb inhibited human tumor growth in vitro and in vivo. ► LAT1 is a promising target molecule for cancer therapy.