miR-27 promotes osteoblast differentiation by modulating Wnt signaling

► MiR-27 levels up-regulate during osteoblastic differentiation. ► Increased miR-27 inhibits APC expression. ► Down-regulation of APC results in accumulation of β-catenin and activating Wnt signaling. ► miR-27promotes osteoblasts differentiation by modulating Wnt signaling.