Sclerostin-erbB-3 interactions: Modulation of erbB-3 activity by sclerostin

► Sclerostin interacts with the carboxyl-terminal domain of the erbB-3 receptor. ► Sclerostin increases erbB-3 receptor signaling following treatment of cells with neuregulin/heregulin. ► Modulation of EGF/erbB signaling in bone by sclerostin is one of the mechanisms by which sclerostin controls bone growth.