Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis

► Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. ► Both genetic and environmental factors may be involved in pathogenesis of ALS. ► Whole-genome screening identifies copy-number gain of IDIs as a risk for ALS.