The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2

► Insects have two different genes, coding for two different forms of the neuropeptide CHHamide (named CCHamide-1 and -2). ► Drosophila has two different genes, coding for two different GPCRs that are specifically activated by either Drosophila CHHamide-1 or -2. ► We have identified two novel neuropeptide signaling systems in insects.