Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement

► A novel lipase, Nceh1 is involved in the cholesterol homeostasis in adrenal glands. ► Nceh1 and Lipe are the major cholesterol ester hydrolases in adrenal glands. ► Deficiency of Nceh1 and/or Lipe causes lipid accumulation in adrenal glands ► Deficiency of these two lipases causes adrenal enlargement. ► Deficiency of the lipases does not affect ACTH-stimulated corticosterone secretion.