Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma

► Th2 cytokines and their downstream JAK-STAT pathways play a critical role in asthma. ► A JAK inhibitor pyridone 6 was encapsulated in nanoparticles. ► We studied the effects of pyridone 6 on asthmatic responses in a mouse model. ► Pyridone 6 treatment during allergen challenge suppressed asthmatic responses.