Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death

► Targeting glutamine metabolism sensitized melanoma to enhanced killing by TRAIL. ► However, normal cells were not killed by the same treatment. ► AOA plus TRAIL enhanced killing of melanoma mediated by caspases. ► AOA plus TRAIL reduced pro-survival proteins (Bcl2, Mcl-1). ► AOA plus TRAIL increased pro death molecule Noxa.