Caspase-dependent inhibition of store-operated Ca2+ entry into apoptosis-committed Jurkat cells

► Fas activation reduces STIM1 and Orai1 protein content in caspase dependent manner. ► Fas activation partially reduces mitochondrial potential in caspase dependent manner. ► Fas stimulation inhibits of store-operated Ca2+ entry in caspase dependent manner. ► Inhibition of Ca2+ entry in apoptotic cells may protect them from secondary necrosis.