Rho A and the Rho kinase pathway regulate fibroblast contraction: Enhanced contraction in constitutively active Rho A fibroblast cells

► Mechanisms of fibroblast cell contraction in collagen matrix. ► Assessed an isometric force development using 3D-reconstituted-fibroblast fiber. ► Constitutively active Rho A induced the over-contraction of fibroblast cells. ► Rho A and Rho kinase pathway has a central role in fibroblast cell contraction.