کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10766810 1050679 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Troponin: Regulatory function and disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Troponin: Regulatory function and disorders
چکیده انگلیسی
Study of the molecular biology of the calcium regulation of muscle contraction was initiated by Professor Ebashi's discovery of a protein factor that sensitized actomyosin to calcium ions. This protein factor was separated into two proteins: tropomyosin and a novel protein named troponin. Troponin is a Ca2+-receptive protein for the Ca2+-regulation of muscle contraction and, in association with tropomyosin, sensitizes actomyosin to Ca2+. Troponin forms an ordered regulatory complex with tropomyosin in the thin filament. Several regulatory properties of troponin, which is composed of three different components, troponins C, I, and T, are discussed in this article. Genetic studies have revealed that many mutations of genes for troponin components, especially troponins T and I, are involved in the three types of inherited cardiomyopathy. Results of functional analyses indicate that changes in the Ca2+-sensitivity caused by troponin mutations are the critical functional consequences leading to these disorders. Recent results of this pathophysiological aspect of troponin are also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 369, Issue 1, 25 April 2008, Pages 62-73
نویسندگان
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