کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10767218 1050718 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Docking of α-cobratoxin suggests a basal conformation of the nicotinic receptor
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Docking of α-cobratoxin suggests a basal conformation of the nicotinic receptor
چکیده انگلیسی
We investigate the interactions between the long chain α-cobratoxin (Cbtx) and the nicotinic acetylcholine receptor using a rigid body docking procedure. The method, (i) reproduces the binding of Cbtx to Lymnea acetylcholine-binding protein (AChBP); (ii) shows that most of the structures of AChBP obtained in the presence of antagonists are compatible with Cbtx binding; and (iii) reveals a complex between Cbtx and muscle nAChR that corresponds to the basal “resting” state conformation. The structures are made available for further understanding of the allosteric transitions of the nAChR as well as for drug design.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 359, Issue 3, 3 August 2007, Pages 413-418
نویسندگان
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