کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10767705 | 1050795 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Presence and active synthesis of the 67Â kDa elastin-receptor in human circulating white blood cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Presence and active synthesis of the 67Â kDa elastin-receptor in human circulating white blood cells Presence and active synthesis of the 67Â kDa elastin-receptor in human circulating white blood cells](/preview/png/10767705.png)
چکیده انگلیسی
Early after the identification of the elastin-receptor (El-R) on mesenchymal cells, it was demonstrated that phagocytic cells and lymphocytes could also respond to elastin peptides. Nevertheless, the level of El-R expression has never been demonstrated on immune cells and no data exist whether these cells actively synthesize this El-R. Thus, our aim in the present work was to study the expression and number of El-R on white blood cells (WBC) using a specific 67Â kDa El-R antibody and to demonstrate the presence of mRNA corresponding to the gene coding for El-R. Our results show that messenger RNA corresponding to the presumptive gene coding for the 67Â kDa El-R subunit could be detected in all three WBC-types investigated. On all of these WBC, the presence of El-R could be demonstrated, however their number and their function varied following the cell type. The presence of El-R is very important for the interaction of circulating cell with the matrix as these cells intervene during atherosclerosis and in host defence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 332, Issue 3, 8 July 2005, Pages 787-792
Journal: Biochemical and Biophysical Research Communications - Volume 332, Issue 3, 8 July 2005, Pages 787-792
نویسندگان
Anis Larbi, Georges Levesque, Ladislas Robert, Daniéle Gagné, Nadine Douziech, Tamas Jr.,