کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10768054 1050803 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deinococcus radiodurans strain R1 contains N6-methyladenine in its genome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Deinococcus radiodurans strain R1 contains N6-methyladenine in its genome
چکیده انگلیسی
Methylation of DNA is known to be involved in DNA repair mechanisms in bacteria. Deinococcus radiodurans strain R1 on exposure to high radiation undergoes significant DNA damage, which is repaired without mutations. However, the presence of modified nucleotides has not been reported in its genome. We report here the detection of N6-methyladenine in the genome of D. radiodurans strain R1 using immunochemical techniques. This N6-methyladenine is not a part of GATC restriction-modification system. D. radiodurans cell extract also exhibited a DNA adenine methyltransferase activity which was reduced in the early post-irradiation recovery phase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 335, Issue 2, 23 September 2005, Pages 412-416
نویسندگان
, , , ,