کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10768402 1050809 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential
چکیده انگلیسی
We identified a 1A6/DRIM (down-regulated in metastasis) interacting protein, KIAA0649 during the yeast two-hybrid screen. The interaction between KIAA0649 and 1A6/DRIM was further confirmed by GST-pull-down and co-immunoprecipitation assays. KIAA0649 was originally identified from human brain tissue. However, its biological function remains unknown. In this report, we showed that KIAA0649 mRNA is widely expressed in human multiple tissues and cell lines. We have also demonstrated that KIAA0649 has oncogenic characteristics: it enhances colony formation, allows anchorage-independent growth. Moreover, KIAA0649 exogenous expression in NIH3T3 fibroblasts caused tumor development in nude mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 334, Issue 3, 2 September 2005, Pages 884-890
نویسندگان
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