کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10769632 | 1050823 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Matrix metalloproteinase-9 (MMP-9) is critically involved in the tumor invasion and metastasis processes. Since TNF-α plays a crucial role in the regulation of MMP-9 expression, the development of molecules capable of modulating TNF-α-induced signaling is an issue of concern. We identified a novel synthetic compound that inhibits TNF-α-induced MMP-9 upregulation in the HT1080 human fibrosarcoma cell line. The active compound SM-7368 inhibited TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and showed maximal activity at 10 μM. SM-7368 inhibited TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. We also found that SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. Moreover, we found that SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line. Taken together, our results demonstrate that SM-7368 is a synthetic compound that inhibits TNF-α-induced MMP-9 expression, and thus SM-7368 should be useful for the development of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 336, Issue 2, 21 October 2005, Pages 716-722
Journal: Biochemical and Biophysical Research Communications - Volume 336, Issue 2, 21 October 2005, Pages 716-722
نویسندگان
Ha Young Lee, Kyoung Sun Park, Mi-Kyoung Kim, Taehoon Lee, Sung Ho Ryu, Kyung Jin Woo, Taeg Kyu Kwon, Yoe-Sik Bae,