کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10769879 1050826 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients
چکیده انگلیسی
We tested the hypothesis that the genetic capability to mount an inflammatory response might contribute to the inter-individual variability of limbal stem cell graft (LSCG) outcome. Two functional polymorphisms in the IL-6 and TNF-α promoter regions were genotyped in 35 patients. A new score system (clinical assessment score, CAS) was set up in order to classify patients' clinical profile, and the main parameters relevant for LSCG as well as for the follow-up of the patients. Patients carrying at both loci a genotype associated with a lower production of both cytokines were classified as “low producers” (LP), while all the others were classified as “intermediate or high producers” (HP). LP patients did not show any difference in CAS before and after transplantation while a significant difference was present in HP patients. A similar trend was evident in the 35 months of follow-up. Polymorphisms of IL-6 and TNF-α can be used to identify subgroups of patients with higher risk of unsuccessful outcome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 332, Issue 1, 24 June 2005, Pages 95-100
نویسندگان
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