کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10770538 | 1050833 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of small heat shock proteins on the thermal denaturation and aggregation of F-actin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of small heat shock proteins on the thermal denaturation and aggregation of F-actin Effects of small heat shock proteins on the thermal denaturation and aggregation of F-actin](/preview/png/10770538.png)
چکیده انگلیسی
Effect of recombinant chicken small heat shock protein with molecular mass 24Â kDa (Hsp24) and recombinant human small heat shock protein with molecular mass 27Â kDa (Hsp27) on the heat-induced denaturation and aggregation of skeletal F-actin was analyzed by means of differential scanning calorimetry and light scattering. All small heat shock proteins did not affect thermal unfolding of F-actin measured by differential scanning calorimetry, but effectively prevented aggregation of thermally denatured actin. Small heat shock protein formed stable complexes with denatured (but not with intact) F-actin. The size of these highly soluble complexes was smaller than the size of intact F-actin filaments. It is supposed that protective effect of small heat shock proteins on the cytoskeleton is at least partly due to prevention of aggregation of denatured actin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 331, Issue 4, 17 June 2005, Pages 1548-1553
Journal: Biochemical and Biophysical Research Communications - Volume 331, Issue 4, 17 June 2005, Pages 1548-1553
نویسندگان
Anastasiya V. Pivovarova, Valeria V. Mikhailova, Ivan S. Chernik, Natalia A. Chebotareva, Dmitrii I. Levitsky, Nikolai B. Gusev,