کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
10770871 1050836 2005 7 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Downregulation of IL-12 and a novel negative feedback system mediated by CD25+CD4+ T cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
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Downregulation of IL-12 and a novel negative feedback system mediated by CD25+CD4+ T cells
چکیده انگلیسی
CD25+CD4+ regulatory T cells suppress immune responses and are believed to play roles in preventing autoimmune diseases. However, the mechanism(s) underlying the suppression and the regulation of their homeostasis remain to be elucidated. Here we show that these regulatory T cells downregulated CD25−CD4+ T-cell-mediated production of IL-12 from antigen-presenting cells, which can act as a growth factor for CD25−CD4+ T cells. We further found that CD25+CD4+ T cells, despite their well-documented “anergic” nature, proliferate significantly in vitro only when CD25−CD4+ T cells are present. Notably, this proliferation was strongly dependent on IL-2 and relatively independent of IL-12. Thus, CD25+CD4+ T cells suppress CD25−CD4+ T-cell responses, at least in part, by inhibiting IL-12 production while they themselves can undergo proliferation with the mediation of CD25−CD4+ T cells in vitro. These results offer a novel negative feedback system involving a tripartite interaction among CD25+CD4+ and CD25−CD4+ T cells, and APCs that may contribute to the termination of immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 330, Issue 1, 29 April 2005, Pages 226-232
نویسندگان
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