کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10770886 1050836 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA
چکیده انگلیسی
Viral infection in the airway provokes various immune responses, including Th1 and Th2 responses, which are partly initiated by double-stranded RNA (dsRNA), a viral product for its replication. B7-H1 (PD-L1) and B7-DC (PD-L2) are B7-family molecules that bind to programmed death-1 (PD-1) on lymphocytes and are implicated in peripheral tolerance. We investigated the effect of dsRNA on the expression of B7-H1 and B7-DC on airway epithelial cell lines. B7-H1 and B7-DC were constitutively expressed on the cells, and their expression was profoundly upregulated by stimulation with an analog of viral dsRNA, polyinosinic-polycytidylic acid. B7-H1 and B7-DC were also upregulated by stimulation with IFN-γ, IL-13, and the supernatant from T cell clones. A relatively high concentration of dexamethasone (1 μM) was required to suppress the upregulation of B7-H1 or B7-DC. These results suggest that epithelial B7-H1 and B7-DC play a role in virus-associated immune responses in the airways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 330, Issue 1, 29 April 2005, Pages 263-270
نویسندگان
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