کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10772111 | 1050847 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prediction of mutation trend in hemagglutinins and neuraminidases from influenza A viruses by means of cross-impact analysis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, we use the cross-impact analysis to define the relationship among impact, mutation, and outbreak of bird flu. Then we use the distribution rank, which is developed by us over last several years, to quantify the mutations from amino acid sequences of 134 hemagglutinins and 97 neuraminidases. With the help of Bayesian equation, we calculate the probability of occurring of mutation in H5, H6, and H9 hemagglutinins, and N1 and N2 neuraminidases. Finally, we estimate the probability of occurring of mutation with different intensities of an impact. Although we have no means to predict an impact, which is severe enough to lead to the mutations in hemagglutinins and neuraminidases resulting in the outbreak of bird flu, we can in principle monitor the changes in distribution rank along the time course, and predict the trend of mutations, even to predict the degree of outbreak of bird flu.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 326, Issue 2, 14 January 2005, Pages 475-482
Journal: Biochemical and Biophysical Research Communications - Volume 326, Issue 2, 14 January 2005, Pages 475-482
نویسندگان
Guang Wu, Shaomin Yan,