Gap junction-mediated electrical transmission: Regulatory mechanisms and plasticity

► Electrical synapses are dynamic and modifiable forms of interneuronal communication. ► The strength of electrical coupling is affected by gap junctional and non-junctional factors. ► Gap junctional conductance is dynamically regulated by nearby glutamatergic synapses. ► PKA and CaMKII, which regulate chemical synapses, also regulate electrical synapses. ► Gap junction regulation necessarily involves the interaction of gap junction channels with scaffold and regulatory proteins.