Growth kinetics of lipid-based nanodiscs to unilamellar vesicles-A time-resolved small angle neutron scattering (SANS) study

► The growth mechanism of lipid-based nanodiscs is examined by time-resolved SANS. ► DLVO theory is used to partially describe the interparticle interaction. ► The growth of the nanodiscs is a reaction-limited coalescence process. ► A nanodisc-to-vesicle transition is observed upon temperature jump. ► The sizes of vesicles are not dictated by those of the pre-annealed discs.