Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences

► Neuronal CaV channels are implicated in neurological and psychiatric diseases. ► Cacna1 genes can generate many CaV channel isoforms through alternative splicing. ► Cell-specific splicing factors control the pool of CaV mRNA splice isoforms. ► Individual splicing events impact cell function and behavior. ► Expression of CaV splice isoforms can influence drug efficacy and disease severity.