What can naturally occurring mutations tell us about Cav1.x channel function?

► Structural homology model for structure-(dys)function analysis in Cav1.x mutants ► Functional 'hotspots' for naturally occurring loss- and gain-of-function mutants ► Gain-of-function mutants interfere with voltage sensor coupling to gate opening. ► Intramolecular interaction in LTCC C-termini with pharmacotherapeutic potential