Biophysics of lipid bilayers containing oxidatively modified phospholipids: Insights from fluorescence and EPR experiments and from MD simulations

► Effects of oxidation on the biophysics of model lipid membranes are reviewed. ► Well-defined oxidized PCs being studied using fluorescence, EPR, and MD are considered. ► Oxidized chains reorient toward water phase and change bilayer properties. ► Structure, phase transition, hydration, fluidity, and flip-flop can be affected.