Influence of stearyl and trifluoromethylquinoline modifications of the cell penetrating peptide TP10 on its interaction with a lipid membrane

► Lipid-peptide interactions of cell-penetrating peptides (CPPs) TP10 and its modified analogs PF3 and PF6. ► Stearylation of TP10 improves insertion into neutral but not anionic lipid monolayers. ► Stearylation of TP10 decreases the membrane permeabilization activity of the modified CPPs. ► Modification of TP10 by trifluoromethylquinoline moieties has relatively little influence on lipid-CPP interaction.