Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes

► Two peptides deriving from HSV glycoproteins B and H interact with lipid bilayers. ► Peptide insertion perturbs lipid packing and dynamics. ► Bilayer composition modulates the peptide-membrane interaction. ► Anionic phospholipids enhance the peptide-bilayer interaction. ► Cholesterol reduces the gH peptide-bilayer interaction.