Pivots of pluripotency: The roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells

► Regulatory non-coding RNAs play important roles in embryonic stem cell processes ► Opposing pro- and anti-differentiation miRNAs regulate pluripotency ► miRNAs can catalyze or enhance the generation of induced pluripotent stem cells ► Long noncoding RNAs are increasingly recognized as regulators of pluripotency ► ncRNAs may define stem cell quality and may also regulate cancer stem cells