Singularities of calcium signaling in effector T-lymphocytes

► Intracellular calcium concentration is differentially regulated in T-cell subsets. ► Cav1 channels contribute to calcium signaling in T-cells. ► The profile of expression of Cav1 channels depends on the state of T-cell activation. ► The singularity of Ca2 + regulation in T-cell subsets is of clinical interest.