Ascorbic acid rescues cardiomyocyte development in Fgfr1−/− murine embryonic stem cells

► Treatment with vitamin (vit) C rescues cardiomyocyte differentiation in Fgfr1−/− mESC. ► The phenotype rescue of vitC is not due to its antioxidant effect. ► The phenotype rescue of vitC is not due to modulation of pluripotency genes. ► FeCl2 rescues cardiomyocyte differentiation in Fgfr1−/− mESC. ► The HIF-1α inhibitor CAY10585 rescues cardiomyocyte differentiation in Fgfr1−/− mESC.