Keywords: Bispecific antibodies; FGFR1; KLB; Pharmaceutical impurities;
مقالات ISI (ترجمه نشده)
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Keywords: HPG; hypothalamic-pituitary-gonadal; GnRH; gonadotropin-releasing hormone; FSH; follicle-stimulating hormone; LH; luteinizing hormone; CNS; central nervous system; HH; hypogonadotropic hypogonadism; PSA-NCAM; polysialic acid form of neural adhesion molecu
Keywords: 18S; 18S ribosomal RNA; 36B4; acidic ribosomal protein 36B4; Acc1; acetyl-CoA carboxylase α; Acox1; acyl-CoA oxidase 1; Apob; apolipoprotein B; ARE; antioxidant response element; AST; aspartate aminotransferase; ALT; alanine aminotransferase; ATF4; activ
Keywords: ACC; acetyl-CoA carboxylase; ALDOA; aldolase A; AIs; aromatase inhibitors; AMPK; AMP-activated protein kinase; BC; breast cancer; CML; chronic myelogenous leukemia; CT; computed tomography; CPT1; carnitine palmitoyltransferase 1; CRC; colorectal cancer; 2
Keywords: Systemic mastocytosis; Hypereosinophilic syndrome; Tyrosine kinase inhibitor; FIP1L1-PDGFRA; FGFR1; JAK2; Imatinib; Midostaurin;
Keywords: Pheochromocytomas; Paragangliomas; MERTK; MET; c-MET; H3F3A; FGFR1; Exome;
Keywords: TIO; tumor-induced osteomalacia; FGF23; fibroblast growth factor 23; 1,25-OH2-vitamin D; 1,25(OH)2D; FGFR1; fibroblast growth factor receptor-1; PTH; parathyroid hormone; TmP/GFR; tubular maximum reabsorption of phosphate to glomerular filtration rate; FD
Keywords: EGFR; FGFR1; Injury; PRP; Scar; VEGF; Vocal fold;
Keywords: Endometriosis; FGFR1; Dysmenorrhea; Recurrence
Keywords: FGFR1; Fibroblast growth factor receptor 1; Amplification; Gastric adenocarcinoma; Gastric cancer; FISH; Fluorescence in situ hybridization
Keywords: Small-cell lung cancer; FGFR1; Focal amplification; Copy number gain
Keywords: AMI; acute myocardial infarction; EMT; epithelial-to-mesenchymal transition; APOA1; apolipoprotein A1; LDLR; low density lipoprotein receptor; FGFR1; fibroblast growth factor 1; ACTA2; smooth muscle alpha-actin; EGF; epidermal growth factor; IL1B; IL-1 be
Keywords: FGFR1; genomic rearrangements; gonadotropin deficiency; mutation; SOX3; WDR11;
Keywords: Essential tremor; Brain; Genetics; Human population; Mouse models; Pathophysiology; ABA; Allen brain atlas; AβPPswe/PS1ÎE9; amyloid-β protein precursor and presenilin-1; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine tri-ph
Keywords: Fibroblast Growth Factor Receptor 1; FGFR1; Oral tongue squamous cell carcinoma; Oral cancer; Fluorescence in situ hybridisation; FISH; Gene amplification; Outcome;
FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p
Keywords: FGFR1; FRS2; Mitochondrial dynamics; miR let-7b-5p;
Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold
Keywords: 1H-Indazol-3-amine and benzohydroxamic acids hybrids; HDACs; FGFR1; Dual inhibitor; MCF-7;
MicroRNAs link chronic inflammation in childhood to growth impairment and insulin-resistance
Keywords: ALS; acid-labile subunit; APC; antigen-presenting cell; CXCL2; chemokine (C-X-C motif) ligand 2; ESR; erythrocyte sedimentation rate; FGFR1; fibroblast growth factor receptor 1; FOXO1; Forkhed box O1; FOXP3; forkhead box P3; GH; growth hormone; GHR; growt
Overexpression of miR-133 decrease primary endothelial cells proliferation and migration via FGFR1 targeting
Keywords: Angiogenesis; Cancer; miR-133; FGFR1;
Fibroblast growth factor 21 ameliorates vascular calcification by inhibiting osteogenic transition in vitamin D3 plus nicotine-treated rats
Keywords: Fibroblast growth factor 21; Vascular calcification; Vascular smooth muscle cells; Osteogenic transition; FGF21; fibroblast growth factor 21; VDN; vitamin D3 plus nicotine; VC; vascular calcification; FGFR1; fibroblast growth factor receptor 1; ALP; alkal
Role of miRNAs in cell signaling of cancer associated fibroblasts
Keywords: ATG; autophagy related; CAF; cancer associated fibroblasts; CCL; C-C motif chemokine ligand; CDK2; cyclin-dependentkinase 2; CXCL; chemokine(C-X-C motif) ligand; DRAM; damage-regulated autophagy modulator; ECM; extracellular matrix; EMT; epithelialto mese
The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer
Keywords: YAP1; FGFR1; TEAD; Cancer stem cell properties; Lung cancer;
Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis
Keywords: DGCs; dentate granule cells; FRS; FGF Receptor Substrate; FGFR1; FGF Receptor 1; IHC; immunohistochemistry; PFA; paraformaldehyde; mEPSCs; miniature excitatory postsynaptic currents; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic
Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFRβ and FGFR1
Keywords: VEGF; vascular endothelial growth factor; FGF-2; fibroblast grow factor 2; PDGF-BB; platelet-derived growth factor-BB; VEGFR2; VEGF receptor 2; FGFR1; FGF receptor 1; PDGFRβ; PDGF receptor β; TKI; tyrosine kinase inhibitor; DMSO; dimethylsulfoxide; BSA;
C1q/TNF-related protein-3 exerts the chondroprotective effects in IL-1β-treated SW1353 cells by regulating the FGFR1 signaling
Keywords: OA; osteoarthritis; CTRP3; C1q/TNF-related protein-3; LPS; lipopolysaccharide; FGFs; fibroblast growth factors; EPCs; endothelial progenitor cells; SDF-1α; stromal cell-derived factor 1α; FGF-2; fibroblast growth factor-2; FGFR1; fibroblast growth facto
Short communicationThe autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding
Keywords: Antibody fragments; FGFR1; Fibroblast growth factor; Receptor autoinhibition; Signal transduction;
Ectopic expression of FGF5s induces wool growth in Chinese merino sheep
Keywords: FGF5; The fibroblast growth factor 5 gene; FGF5s; Fibroblast growth factor 5-short; FGF; The fibroblast growth factor; FGFR1; The fibroblast growth factor receptor1; FGFR2; The fibroblast growth factor receptor2;
Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures
Keywords: FGFR1; M1 receptor; Transactivation; Heteroreceptor complexes; Neural plasticity;
A dominant negative FGFR1 mutation identified in a Kallmann syndrome patient
Keywords: KS; Kallmann syndrome; IHH; isolated hypogonadotropic hypogonadism; FGFR1; fibroblast growth factor receptor 1; GnRH; gonadotropin-releasing hormone; PI3K; phosphiosidtide 3-linase; PLC; phospholipase C; PKC; protein kinase C; PCR; polymerase chain reacti
Targeted inhibition of Klotho binding to fibroblast growth factor 23 prevents hypophosphetemia
Keywords: FGFR1; FGF23; Molecular dynamics simulation;
ITE Suppresses Angiogenic Responses in Human Artery and Vein Endothelial Cells: Differential Roles of AhR
Keywords: AhR; Aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; CYP1A1; cytochrome P450 family 1 member A1; CYP1B1; cytochrome P450 family 1 member B1; BM; basal RPMI 1640 media; CGM; complete growth medium; FBS; fetal bovine serum; FGF2; fibroblast growth factor
Comparative effect of imatinib and ponatinib on autophagy and miRNome in chronic myeloid leukemia
Keywords: TKI; tyrosine kinase inhibitor; CML; chronic myeloid leukemia; LSC; leukemia stem cells; WST-1; Water Soluble Tetrazolium-1; GFP; Green Florescent Protein; TR-FRET; Time-resolved Fluorescence Energy Transfer; LC3B; light chain 3 B; miRNA; Micro Ribonuclei
Acute lung injury complicating acute kidney injury: A model of endogenous αKlotho deficiency and distant organ dysfunction
Keywords: 8-OHdG; 8-hydroxy-â²-deoxyguanosine; AKI; Acute kidney injury; ARDS; Acute respiratory distress syndrome; ARE; Antioxidant response element; EpoR; Erythropoietin receptor; FGF; Fibroblast growth factor; FGFR1; Fibroblast growth factor receptor-1; IGF-1;
Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice
Keywords: Fibroblast growth factor 21; FGF21; Fibroblast growth factor receptor 1; FGFR1; β-klotho; KLB; bGH mice; GHR −/− mice
Altered FGF signalling in congenital craniofacial and skeletal disorders
Keywords: FGF signalling; FGFR1; FGFR2; FGFR3; Bone development; Craniosynostosis; Skeletal dysplasia;
AKT inactivation causes persistent drug tolerance to EGFR inhibitors
Keywords: SCLC; small cell lung cancer; NSCLC; non-small-cell lung cancer; TKIs; tyrosine kinase inhibitors; RTK; receptor tyrosine kinase; EGFR; epidermal growth factor receptor; IGF-1R; insulin-like growth factor 1 receptor; FGFR1; fibroblast growth factor recept
Functional conservation and divergence of duplicated fibroblast growth factor receptor 1 (fgfr1) genes in blunt snout bream (Megalobrama amblycephala)
Keywords: Fgfr1/fgfr; fibroblast growth factor receptor; Fgf; fibroblast growth factor; MHB; mid-hindbrain boundary; RTKs; receptor tyrosine kinases; HSPG; heparan sulfate proteoglycan; PKC; protein kinase C; PI3K; phosphoinositide 3-kinase; ERKs; extracellular sig
Novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: evidence for the involvement of an alternatively spliced isoform
Keywords: Hypogonadotropic hypogonadism; Kallmann syndrome; FGFR1; KAL2; genetics;
Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one
Keywords: ASK1; apoptosis signal-regulating kinase 1; MAPK; mitogen-activated protein kinase; ER; endoplasmic reticulum; TNF-α; tumor necrosis factor-alpha; AIP-1; ASK1-interacting protein 1; VEGF; vascular endothelial growth factor; Aβ; amyloid beta; CK2; protei
NEDD4: The founding member of a family of ubiquitin-protein ligases
Keywords: RING; Really Interesting New Gene; HECT; Homologous to E6-AP C-Terminus; Ndfip1; Nedd4 family interacting protein 1; AMPARs; alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptors; EGFR; epidermal growth factor receptor; FGFR1; Fibroblast gro
NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium
Keywords: CAVD; calcific aortic valve disease; ALP; alkaline phosphatase; IBSP; bone sialoprotein; SPARC; osteonectin; TGFβ; transforming growth factor beta; WNT; wingless-type MMTV integration site family; CSL; suppressor of hairless; MAML; mastermind-like protei
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
Keywords: Brown adipose tissue; Therapeutic antibody; Thermogenesis; Adipose tissue browning; Humanized antibody; Adiponectin; FGF21; FGF19; FGFR1; betaKlotho; UCP1; Bispecific antibody; Insulin resistance; Obesity; Type 2 diabetes; Hepatosteatosis; NASH
The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer
Keywords: FGFR1; Small cell lung cancer; Prognosis; Biomarker; Amplification; FISH;
Investigation of FGF1 and FGFR gene polymorphisms in a group of Iranian patients with nonsyndromic cleft lip with or without cleft palate
Keywords: FGF1; FGFR1; Cleft lip and/or cleft palate; Single nucleotide polymorphism
5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19
Keywords: GPCRs; G protein coupled receptors; RGS; regulator of G protein signaling; GAP; GTPase accelerating protein; RH; RGS homology domain; shRNA; short hairpin RNA; GFP; green fluorescent protein; IBMX; 3-isobutyl-1-methylxanthine; MAPK; mitogen-activated prot
High rate of FGFR1 amplifications in brain metastases of squamous and non-squamous lung cancer
Keywords: FGFR1; Gene amplification; Fluorescent in situ hybridization; Brain metastases; Lung cancer;
Discovery and identification of new non-ATP competitive FGFR1 inhibitors with therapeutic potential on non-small-cell lung cancer
Keywords: FGFR1; Non-ATP competitive inhibition; Selectivity; Irreversible FGFR1 inhibitors; Lung cancer
The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy
Keywords: BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate
Riluzole increases glutamate uptake by cultured C6 astroglial cells
Keywords: ALS; amyotrophic lateral sclerosis; EAAT; excitatory amino acid transporter; PKC; protein kinase C; PI3K; phosphatidylinositol 3-kinase; FGFR1; fibroblast growth factor receptor 1; FRS2α; FGFR substrate 2α; MAPK; mitogen-activated protein kinase; ERK; e
Matrix metalloproteinase-2 deletions protect against hemorrhagic transformation after 1Â h of cerebral ischemia and 23Â h of reperfusion
Keywords: BBB; blood-brain barrier; EDTA; ethylenediaminetetraacetic acid; FGF; fibroblast growth factor; FGFR1; FGF receptor type 1; HT; hemorrhagic transformation; KO; knockout; MCAO; middle cerebral artery occlusion; MCID; microcomputer image device; MMP; matr