CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis

► CAND1 preferentially blocks Skp2 integration into CRL1s in human cells. ► CAND1 knockdown causes Skp2 assembly into CRL1s and a significant decrease of p27. ► CAND1 increases in preadipocyte differentiation associated with elevation of p27. ► Knockdown of CAND1 in preadipocytes blocks adipogenesis.