Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration

► In hepatoma cell-types with low differentiation grade, miR-198 expression was prominently reduced. ► Central signal transducers of proliferation pathways were controlled by miR-198. ► miR-198 upregulates synthesis of E-cadherin and claudin-1, involved in cell adhesion and cell-cell contacts. ► miR-198 acts as a tumor suppressor by repression of mitogenic and motogenic activities.