Structure and function of the AAA+ nucleotide binding pocket

► We provide an overview of the current classification of AAA+ proteins. ► The characteristic features of the AAA+ nucleotide binding pocket are presented. ► We assemble biochemical data summarising the effects of site directed mutations in the nucleotide binding pocket. ► We assess the structural conservation of AAA+ domains and their nucleotide binding pockets. ► PDB structures of oligomeric AAA+ proteins are examined regarding protomer interactions at the nucleotide binding pocket.