Mitochondria adjust Ca2+ signaling regime to a pattern of stimulation in salivary acinar cells

► Extensive secretion requires an adaption of acinar cell Ca2+-signaling machinery. ► We model two types of cell stimulation: short and prolonged presence of an agonist. ► Upon short stimulation mitochondria slightly regulate Ca2+ entry and ER refilling. ► Upon prolonged stimulation mitochondria ensure sustained Ca2+ entry and ER refilling. ► Mitochondria take up and release Ca2+ within Ca2+ microdomains.