کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10803652 | 1057176 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mesenchymal stem cell secretome and regenerative therapy after cancer
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CSCFSP1adipose-derived stem/stromal cellsSDF1HDGFfibroblast-specific protein-1HGFCXCLPDGFCCLMCP1INFγIPSCMSCTGFβMesenchymal stromal/stem cellsASCMMPEGFHSCTNFαIL-6ECMinterferon-gamma - اینترفرون گاماinterleukin-6 - اینترلوکین ۶umbilical cord - بند نافtransforming growth factor-beta - تبدیل فاکتور رشد بتاtumor necrosis factor-alpha - تومور نکروز عامل آلفاEMT - تکنسین فوریتهای پزشکیhematopoietic stem cells - سلول های بنیادی خونسازInduced pluripotent stem cell - سلول های بنیادی پلوروپتوژن منجر شده استtumor-initiating cells - سلولهای آغاز کننده تومورMesenchymal stem/stromal cells - سلولهای ساقه / استرومال MesenchymalCancer stem cells - سلولهای بنیادی سرطانیepidermal growth factor - عامل رشد اپیدرمیHepatocyte growth factor - عامل رشد هپاتوسیتhepatoma-derived growth factor - عامل رشد هپاتوماCancer recurrence - عود سرطانstromal cell-derived factor-1 - فاکتور 1 حاصل از استروما سلولVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)platelet-derived growth factor - فاکتور رشد حاصل از پلاکتTumor-associated fibroblasts - فیبروبلاست های مرتبط با تومورextra-cellular matrix - ماتریکس خارج سلولیMatrix metalloproteinases - متالوپروتئیناز ماتریکسbone marrow - مغز استخوانTAF - می دانمmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1Epithelial–mesenchymal transition - گذار اپیتلیال-مزانشیمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cancer treatment generally relies on tumor ablative techniques that can lead to major functional or disfiguring defects. These post-therapy impairments require the development of safe regenerative therapy strategies during cancer remission. Many current tissue repair approaches exploit paracrine (immunomodulatory, pro-angiogenic, anti-apoptotic and pro-survival effects) or restoring (functional or structural tissue repair) properties of mesenchymal stem/stromal cells (MSC). Yet, a major concern in the application of regenerative therapies during cancer remission remains the possible triggering of cancer recurrence. Tumor relapse implies the persistence of rare subsets of tumor-initiating cancer cells which can escape anti-cancer therapies and lie dormant in specific niches awaiting reactivation via unknown stimuli. Many of the components required for successful regenerative therapy (revascularization, immunosuppression, cellular homing, tissue growth promotion) are also critical for tumor progression and metastasis. While bi-directional crosstalk between tumorigenic cells (especially aggressive cancer cell lines) and MSC (including tumor stroma-resident populations) has been demonstrated in a variety of cancers, the effects of local or systemic MSC delivery for regenerative purposes on persisting cancer cells during remission remain controversial. Both pro- and anti-tumorigenic effects of MSC have been reported in the literature. Our own data using breast cancer clinical isolates have suggested that dormant-like tumor-initiating cells do not respond to MSC signals, unlike actively dividing cancer cells which benefited from the presence of supportive MSC. The secretome of MSC isolated from various tissues may partially diverge, but it includes a core of cytokines (i.e. CCL2, CCL5, IL-6, TGFβ, VEGF), which have been implicated in tumor growth and/or metastasis. This article reviews published models for studying interactions between MSC and cancer cells with a focus on the impact of MSC secretome on cancer cell activity, and discusses the implications for regenerative therapy after cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 95, Issue 12, December 2013, Pages 2235-2245
Journal: Biochimie - Volume 95, Issue 12, December 2013, Pages 2235-2245
نویسندگان
Ludovic Zimmerlin, Tea Soon Park, Elias T. Zambidis, Vera S. Donnenberg, Albert D. Donnenberg,