What does make an amyloid toxic: Morphology, structure or interaction with membrane?

► HET-s(218-289) versus M8 mutant: a model of amyloid toxicity. ► Antiparallel FTIR signature as a predictor of amyloid toxicity? ► Membrane influences the kinetic of amyloid fibrillization. ► Membrane as cellular target of antiparallel species. ► Toxic amyloids induce membrane disruption: the “amyloid-raft” model.