A mouse model of in vivo chemical inhibition of retinal calcium-independent phospholipase A2 (iPLA2)

► BEL was the most powerful inhibitor of iPLA2 among the different molecules tested. ► The retina was more susceptible than the brain to iPLA2 inhibition by BEL. ► Intraperitoneal injection of BEL in mice inhibited retinal iPLA2 activity by 50%. ► Repeated treatments with BEL in mice maintained such an inhibition over seven days.