Methylenebisphosphonate and triphosphate derivatives of the mevalonate pathway are substrates of yeast UTP:glucose-1-phosphate uridylyltransferase

► Uridylyltransferase transfers UMP to the bisphosphonate pCH2p forming UppCH2p. ► This enzyme forms UppppMev from triphosphate derivatives of mevalonate(Mev). ► Connections with the effect of bisphosphonates on osteoporosis are suggested.