Clearance of yeast prions by misfolded multi-transmembrane proteins

► Misfolded multi-transmembrane (MTM) proteins trigger clearance of yeast prions. ► Excess MTM protein induces HSR, but not UPR, and abnormally accumulates in the ER. ► The get3Δ deletion mutant disables the prion clearance. ► The GET pathway might be involved in quality control of MTM proteins and prions.