A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

► We model the cholesterol biosynthesis pathway and its regulation. ► The innate immune response leads to a suppression of flux through the pathway. ► Statin inhibitors show a different mode of suppression to the immune response. ► Statin inhibitor suppression is less robust and less specific than immune suppression.