The periodontal pathogen Porphyromonas gingivalis induces the Epstein-Barr virus lytic switch transactivator ZEBRA by histone modification

► Porphyromonas gingivalis induced EBV reactivation via chromatin modification. ► EBV reactivation was associated with P. gingivalis-produced butyric acid accumulation. ► P. gingivalis induced both histone acetylation and BZLF1 transcriptional activity.