Oxidative stress-dependent oligomeric status of erythrocyte peroxiredoxin II (PrxII) during storage under standard blood banking conditions

► The existence of at least 4 stable aggregations states of RBC PrxII was demonstrated. ► An active hetero-oligomer composed by catalase (CAT) and PrxII has been discovered. ► Oxidative stress-related structural and functional switches in PrxII were documented. ► The CAT-PrxII complex migrates from cytosol to membrane following oxidative insult. ► We showed that PrxII is an effective redox-sensitive regulator in storage lesions.