Isoform-specific roles of the GTPase activating protein Nadrin in cytoskeletal reorganization of platelets

► Nadrin is a new GAP for Rho GTPases in platelets and megakaryocytes. ► Nadrin isoforms selectively regulate Rho proteins and cytoskeletal reorganization. ► The C-terminus of Nadrin determines Rho specificity and influences cell physiology. ► Nadrin controls cell adhesion mediated by Rho proteins. ► Unexpectedly, Nadrin-GAP activity is regulated by the BAR domain.