کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10815818 | 1058505 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of nitric oxide produced by iNOS through NF-κB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of nitric oxide produced by iNOS through NF-κB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide Role of nitric oxide produced by iNOS through NF-κB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide](/preview/png/10815818.png)
چکیده انگلیسی
LPS increased NO
- - production, iNOS protein levels and NF-κB nuclear levels; concomitantly with NO
- - production, LPS increased the neuronal migration as compared to non stimulated cultures. The necessary roles of the NO
- - and iNOS were demonstrated by chelating of NO
- - with hemoglobin and the inhibition of iNOS by 1400 W. Each of these treatments reduced neuronal migration induced by LPS. The role of NF-κB was showed by using the inhibitor JSH-23, which decreased NO
- - production and neuronal migration in LPS activated cultures. These results suggest that neuronal migration during development is susceptible to be modified by pro-inflammatory stimulus such as LPS through intracellular pathways associated with their receptors.
- - production, iNOS protein levels and NF-κB nuclear levels; concomitantly with NO
- - production, LPS increased the neuronal migration as compared to non stimulated cultures. The necessary roles of the NO
- - and iNOS were demonstrated by chelating of NO
- - with hemoglobin and the inhibition of iNOS by 1400 W. Each of these treatments reduced neuronal migration induced by LPS. The role of NF-κB was showed by using the inhibitor JSH-23, which decreased NO
- - production and neuronal migration in LPS activated cultures. These results suggest that neuronal migration during development is susceptible to be modified by pro-inflammatory stimulus such as LPS through intracellular pathways associated with their receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 23, Issue 2, February 2011, Pages 425-435
Journal: Cellular Signalling - Volume 23, Issue 2, February 2011, Pages 425-435
نویسندگان
Daniela Arias-Salvatierra, Ellen K. Silbergeld, Leonor C. Acosta-Saavedra, Emma S. Calderon-Aranda,