کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10817231 | 1058749 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drebrin and cognitive impairment
ترجمه فارسی عنوان
دریبین و اختلال شناختی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The kinetics of cytoskeletal networks, with actin as a key factor, play a key role in regulating the morphology and function of dendritic spines. Drebrin is a neuron growth and brain development-related actin-binding protein and is present in 70% of the dendritic spines of excitatory synapses. It regulates the development and formation of dendritic spines and well-developed dendritic spines pave the way for presynaptic elements. Well-developed and mature synapses are prerequisite for maintaining nervous system physiology. Abnormal morphology of dendritic spines and loss of synapses are seen in many neurologic diseases associated with cognitive decline. However, the mechanisms governing these pathologic changes and their correlation with drebrin remain unclear. Exploring the relationship between drebrin and cognitive function may provide insight into the early prevention of cognitive impairment and in the diagnosis and treatment of Alzheimer's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 451, Part B, 7 December 2015, Pages 121-124
Journal: Clinica Chimica Acta - Volume 451, Part B, 7 December 2015, Pages 121-124
نویسندگان
Lina Ma, Yun Li, Rong Wang,