کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10820594 | 1060724 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of CCAAT/enhancer binding protein δ is closely associated with degeneration of surface mucous cells of larval stomach during the metamorphosis of Xenopus laevis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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![عکس صفحه اول مقاله: Expression of CCAAT/enhancer binding protein δ is closely associated with degeneration of surface mucous cells of larval stomach during the metamorphosis of Xenopus laevis Expression of CCAAT/enhancer binding protein δ is closely associated with degeneration of surface mucous cells of larval stomach during the metamorphosis of Xenopus laevis](/preview/png/10820594.png)
چکیده انگلیسی
CCAAT/enhancer binding protein δ (C/EBP δ) is one of the transcription factors that have a basic-leucine zipper domain. In mammals, it has been suggested that this transcription factor plays a role in differentiation of adipocytes or in apoptosis of mammary gland epithelial cells. The factor also plays a role in acute-phase response in injury, infection and inflammation. We cloned Xenopus homologues of the C/EBP δ gene from metamorphosing stomach by subtractive hybridization and analyzed spatio-temporal expression pattern of the homologues. Two isoforms of C/EBP δ were isolated and named C/EBP δ-1 and â2. Their deduced amino acid sequences were highly similar to each other (identity, 91.2%). Expression of the C/EBP δ mRNAs in the stomach transiently increased during its metamorphosis-associated remodeling, and the transient up-regulation was also found in thyroid hormone-induced metamorphosis. The C/EBP δ mRNAs were exclusively localized in degenerating larval surface mucous cells, not in newly proliferating and differentiating adult-type epithelial cells. The result suggests a possibility that Xenopus C/EBP δ plays a role in apoptotic cell death of larval-type epithelium during the stomach remodeling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Volume 140, Issue 3, March 2005, Pages 505-511
Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Volume 140, Issue 3, March 2005, Pages 505-511
نویسندگان
Masayuki Ikuzawa, Ken-ichiro Kobayashi, Shigeki Yasumasu, Ichiro Iuchi,