کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10823564 | 1061898 | 2010 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rad54, the motor of homologous recombination
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کلمات کلیدی
BLMDSBRSDSARecQ helicasesWRNsynthesis-dependent strand annealingHolliday junctions - اتصالات HollidayEscherichia coli - اشریشیا کُلیDNA double-strand break repair - تعمیر DNA شکست دو رشتهD-loop - حلقه DSaccharomyces cerevisiae - ساکارومایسس سرویزیهBranch migration - مهاجرت شعبهDrosophila melanogaster - مگس سرکه، مگس میوهHomo sapiens - نام علمی انسانHomologous recombination - نوترکیبی همولوگ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Homologous recombination (HR) performs crucial functions including DNA repair, segregation of homologous chromosomes, propagation of genetic diversity, and maintenance of telomeres. HR is responsible for the repair of DNA double-strand breaks and DNA interstrand cross-links. The process of HR is initiated at the site of DNA breaks and gaps and involves a search for homologous sequences promoted by Rad51 and auxiliary proteins followed by the subsequent invasion of broken DNA ends into the homologous duplex DNA that then serves as a template for repair. The invasion produces a cross-stranded structure, known as the Holliday junction. Here, we describe the properties of Rad54, an important and versatile HR protein that is evolutionarily conserved in eukaryotes. Rad54 is a motor protein that translocates along dsDNA and performs several important functions in HR. The current review focuses on the recently identified Rad54 activities which contribute to the late phase of HR, especially the branch migration of Holliday junctions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 9, Issue 3, 2 March 2010, Pages 286-302
Journal: DNA Repair - Volume 9, Issue 3, 2 March 2010, Pages 286-302
نویسندگان
Alexander V. Mazin, Olga M. Mazina, Dmitry V. Bugreev, Matthew J. Rossi,