کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10823646 | 1061914 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nucleotide excision repair in chromatin and the right of entry
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کلمات کلیدی
ATP-utilizing chromatin assembly and remodeling factorTFIIH6-4PPstranscription factor IIHRADiation sensitiveISWIRADERCCCBPNTSUASTCrACFRNA polymerase II - آرانای پلیمراز II 6-4 photoproducts - 6-4 عکاسی محصولاتcpd - CPDNER - DOWNxeroderma pigmentosum - pigmentosum xerodermaSWI/SNF - SWI / SNFUltraviolet - اشعه فرابنفشGGR - بارexcision repair cross-complementing - تعمیر مجدد متقابل مکملnucleotide excision repair - تعمیر مجدد نوکلئوتیدیGlobal genomic repair - تعمیر ژنوم جهانیupstream activating sequence - دنباله فعال سازی بالادستcyclobutane pyrimidine dimer - دییریر پیریمیدین cyclobutanetranscribed strand - رشته رونویسیtranscription coupled repair - رونویسی همراه با تعمیرimitation switch - سوئیچ تقلبیCockayne syndrome - سکته CockayneHistone acetyltransferase - هیستون استیل ترانسفرازHistones - هیستون هاCREB binding protein - پروتئین اتصال CREBPol II - پل دومHAT - کلاه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
DNA is packaged with histones and other accessory proteins into chromatin in eukaryotic cells. It is well established that the assembly of DNA into chromatin affects induction of DNA damage as well as repair of the damage. How the DNA repair machinery detects a lesion and 'fixes it' in chromatin has been an intriguing question since the dawn of understanding DNA packaging in chromatin. Direct recognition/binding by damaged DNA binding proteins is one obvious tactic to detect a lesion. Rearrangement of chromatin structure during DNA repair was reported more than two decades ago. This early observation suggests that unfolding of chromatin structure may be required to facilitate DNA repair after lesions are detected. Cells can also exploit DNA processing events to assist DNA repair. Transcription coupled repair (TCR) is such an example. During TCR, an RNA polymerase blocked by a lesion, may act as a signal to recruit DNA repair machinery. Possible roles of histone modification enzymes, ATP-dependent chromatin remodeling complexes and chromatin assembly factors in DNA repair are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 4, Issue 8, 28 July 2005, Pages 884-896
Journal: DNA Repair - Volume 4, Issue 8, 28 July 2005, Pages 884-896
نویسندگان
Feng Gong, YoungHo Kwon, Michael J. Smerdon,